NKRF and hepatocellular carcinoma: These results align with previously established mechanisms of lncRNA-mediated necroptosis modulation, for instance, lncRNA NRF suppresses miR-873, leading to the activation of RIP1/RIP3 (53), while depletion of LINC00176 has been shown to disrupt the cell cycle and induce necroptosis in hepatocellular carcinoma via the release of tumor-suppressive miRNAs (54).