In the high-score group, gap junction, ECM–receptor interaction, focal adhesion, regulation of the actin cytoskeleton, calcium signaling pathway, phosphatidylinositol signaling system, and JAK STAT signaling pathway among the top 15 pathways were strongly associated with tumor progression and metastasis, whereas other pathways, such as melanoma, renal cell carcinoma, and glioma, were also enriched, which proves that these necroptosis-related lncRNAs may also play a role in pancancer regulation (Supplementary Figure S1A). Here, SOAT1 is linked to melanoma.