Current predictive markers, including PD-L1 expression, tumor mutational burden (TMB), and microsatellite instability (MSI), exhibit limited specificity in ICC due to its unique molecular landscape, characterized by low TMB, frequent FGFR2 fusions, and predominantly microsatellite-stable (MSS) status (3, 4). Here, CD274 is linked to intrahepatic cholangiocarcinoma.