Several other chemokines were associated with Fusobacterium, including the CXCL chemokines C-X-C motif chemokine ligand 10 (CXCL10) and C-X-C motif chemokine ligand 11 (CXCL11) and the (C-C motif) ligand (CCL) chemokines CCL3 and CCL4. CXCL10 and CXCL11 may be primarily produced by myeloid cells in the tumor microenvironment (18, 27, 45–47), and several reports suggest that CXCL10 and CXCL11 have anti-tumor effects in CRC, possibly by recruiting cytotoxic lymphocytes to the tumor (48–51). Here, CCL4 is linked to neoplasm.