For instance, Kaposi’s sarcoma-associated herpesvirus utilizes its viral protein vIRF3 in cooperation with host TFs IRF4 and BATF to engage SEs, thereby regulating the expression of key survival genes such as IRF4, CCND2, MYB, and PIK3C3 in primary effusion lymphoma(PEL) and promoting tumor cell growth (117). This evidence concerns the gene IRF4 and primary effusion lymphoma.