For instance, Kaposi’s sarcoma-associated herpesvirus utilizes its viral protein vIRF3 in cooperation with host TFs IRF4 and BATF to engage SEs, thereby regulating the expression of key survival genes such as IRF4, CCND2, MYB, and PIK3C3 in primary effusion lymphoma(PEL) and promoting tumor cell growth (117). The gene discussed is IRF4; the disease is neoplasm.