In MS, the vitamin D receptor (VDR) binds 1,25(OH)2D3 to form SEs at risk loci such as ZMIZ1, EOMES, DENND6B, and USP2, where MS-associated SNPs (e.g., rs6589939) co-localize with PU.1 in open chromatin. The gene discussed is SPI1; the disease is myeloid sarcoma.