Furthermore, Akkermansia muciniphila increased SCFAs, reduced plasma endotoxins and TNF-α, IL-1β, and IL-6, and synergistically protectd blood-brain barrier integrity by upregulating the expression of intestinal Claudin-2/3 and cerebral Claudin-5, thereby improving post-stroke cognitive impairment (Li et al., 2023). The gene discussed is IL1B; the disease is Cognitive impairment.