The research of Professors Sanjay K. Nigam et al. revealed the core bridging role of OAT1/OAT3 in the interaction between UA metabolism and intestinal microbiota, constructed the theoretical framework of the GLK axis, and laid a revolutionary theoretical foundation for the mechanism research, prevention, and treatment of hyperuricemia and chronic kidney disease. The gene discussed is SLC22A6; the disease is chronic kidney disease.