FOCAD and non-small cell lung carcinoma: The inhibition of NRF2 results in the phosphorylation of focal adhesion kinase and the subsequent reduction in the activity of the mitochondrial, ETC., complex I by negatively regulating the expression of FOCAD, which in turn leads to a decrease in the expression of TCA cycle intermediates α-KG and succinate. Additionally, the activity of the TCA cycle is attenuated, which ultimately reduces the susceptibility of NSCLC cells to cysteine deprivation-induced iron death and promotes NSCLC progression