BIX reduces the fuel source for the TCA cycle by decreasing the expression level of branched-chain α-keto acid dehydrogenase, which in turn leads to a significant reduction in the level of TCA cycle intermediates as well as the inhibition of mitochondrial metabolism, which ultimately leads to the apoptosis of EGFR-mutated NSCLC cells. This evidence concerns the gene EGFR and non-small cell lung carcinoma.