PCOS is marked by hyperandrogenism, oligo-anovulation, and polycystic ovarian morphology, and its pathophysiology includes an increased frequency of GnRH pulses, which disproportionately elevate LH over FSH, contributing to impaired follicular maturation and excess ovarian androgen production [6], [7]. This evidence concerns the gene GNRH1 and polycystic ovary syndrome.