Eumenorrheic individuals showed mid-cycle estradiol peaks and LH surges typical of ovulatory cycles [1], whereas PCOS profiles reproduced hallmark features such as chronic LH elevation, hyperandrogenism, and suppressed FSH, a pattern consistent with disrupted folliculogenesis and increased GnRH pulse frequency [6], [39]. The gene discussed is PLOD1; the disease is polycystic ovary syndrome.