,6,9 HNSCC arises from mucosal linings and is driven by both external carcinogens and genetic alterations (e.g., Fanconi Anaemia Complementation Group [FANC], Grainyhead-like 3 [GRHL3], Filaggrin [FLG], Y-box binding protein 1 [YBX1]).10, 11, 12, 13 Oropharyngeal cancers are increasingly HPV-driven, with projections indicating HPV-positive cases may predominate in the near future.14 The gene discussed is YBX1; the disease is oropharynx cancer.