SAV1 and neoplasm: This discovery provided critical insights into the conservation of signaling mechanisms across species and included the recognition of four tumor suppressors: Warts (Wts), a nuclear dbf2‐related (NDR) family protein kinase; Salvador (Sav), a WW domain‐containing scaffold protein; Hippo (Hpo), a Ste20‐like protein kinase; and Mob‐as‐tumor suppressor (Mats), an adaptor protein.