Further analysis revealed that K193 lactylation on Eno1 was significantly upregulated not only in the PECs of ARDS mice (Figure 5H and Figure S10B,C), but also in LPS‐treated MPMECs (Figure 5I) and HULEC‐5a cells (Figure S10D) in vitro. This evidence concerns the gene ENO1 and acute respiratory distress syndrome.