MAPT and Alzheimer disease: Comparative analyses of these polyphenols across different in vivo and in vitro AD models reveal differential efficacy; for example, EGCG has shown pronounced inhibition of amyloid‐beta aggregation and ROS generation in transgenic mouse models, whereas curcumin primarily targets tau phosphorylation and microglial activation via downregulation of NF‐κB and MAPK pathways (Henríquez et al. 2020; Wu et al. 2022).