In this study, two‐sample MR was performed to evaluate the causal relationship between FODMAP‐related dietary intake and liver cancer risk, followed by a two‐step MR to investigate whether proteins involved in efferocytosis and trogocytosis, specifically TGFB3, EPOR, ELANE, and C3, mediate these effects. Here, TGFB3 is linked to liver cancer.