NF2 and hearing loss disorder: However, considering concurrent neuronal loss, uncontrolled Schwann cell proliferation and lack of temporal matching of SNHL and tumor growth clinically, we postulate our findings of macrophagic activation in NF2-SWN may be part of a coordinated inflammatory response within the cochlea due to aberrant Schwann cell function independent of tumor effects, and potentially contributing to pathogenesis of hearing loss.