However, considering concurrent neuronal loss, uncontrolled Schwann cell proliferation and lack of temporal matching of SNHL and tumor growth clinically, we postulate our findings of macrophagic activation in NF2-SWN may be part of a coordinated inflammatory response within the cochlea due to aberrant Schwann cell function independent of tumor effects, and potentially contributing to pathogenesis of hearing loss. This evidence concerns the gene NF2 and neoplasm.