In animal models of neurodegenerative disease, multi-sensory stimulation interventions such as environmental enrichment, which refers to housing animals in a complex environment with toys, running wheels, and varied stimuli to promote sensory and motor engagement have demonstrated potential regulatory effects—e.g., increased striatal dopamine transporter (DAT) density in α-synuclein transgenic mice after 12 weeks of training. Here, SLC6A3 is linked to neurodegenerative disease.