TRPA1 and ischemia: Our data, however, would suggest that BCAS 14d and 28d mouse brains showed evidence of an anti-inflammatory or neuroprotective state as shown by a significant increase in the expression of S100A10 [51,52], IL-10 [53], Nrf2 [54], and TRPA1, all of which have been linked to ischemia-induced neuroprotection.