In focal segmental glomerulosclerosis (FSGS), mechanistically dysregulated m6A dynamics contribute to glomerular dysfunction through METTL14-mediated m6A modifications that suppress Sirt1 expression-a nephroprotective deacetylase-in both murine models and human podocytes (Lu et al., 2021). The gene discussed is SIRT1; the disease is focal segmental glomerulosclerosis.