Complementing these, metabolic-epigenetic circuitry underlies disease-specific adaptations: METTL3 stabilizes c-Myc to enhance glycolytic flux in polycystic kidney disease, METTL14 regulates TUG1 lncRNA to activate MAPK signaling in diabetic tubular injury, and METTL14 deficiency promotes Warburg-like remodeling via BPTF stabilization in renal carcinoma (Ramalingam et al., 2021; Zhang et al., 2021; Zheng et al., 2023). The gene discussed is METTL14; the disease is polycystic kidney disease.