Parallel investigations in autosomal dominant polycystic kidney disease (ADPKD) reveal METTL3 upregulation correlating with cystogenesis, where mechanistically elevated methionine and SAM levels enhance METTL3 activity, promoting m6A-dependent stabilization of c-Myc and Avpr2 transcripts to facilitate cyst growth through c-Myc-driven proliferation and cAMP pathway activation (Ramalingam et al., 2021). Here, AVPR2 is linked to autosomal dominant polycystic kidney disease.