Collectively, these disease-specific regulatory networks highlight distinct mechanistic pathways: alcohol-associated injury involves FTO/YTHDF2-mediated inflammatory activation, ADPKD centers on METTL3-driven metabolic-epigenetic crosstalk, and FSGS links to METTL14-dependent Sirt1 downregulation. Here, METTL3 is linked to autosomal dominant polycystic kidney disease.