In addition, it has been discovered that insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) can upregulate the expression of macrophage migration inhibitory factor (MIF) by enhancing E2F transcription factor 1 (E2F1) through m6A modification, which subsequently leads to podocyte apoptosis in SA-AKI (Mao et al., 2023). Here, E2F1 is linked to acute kidney injury.