CLDN1 and chronic kidney disease: It was observed that the core genes most significantly positively correlated with CKD onset were CCL2 and MMP7, while the core genes most significantly negatively correlated were GGT6, PCK2, SFXN2, SLC34A3, ALPL, GLTPD2, ACADM, and SUCLG1. The core genes most significantly positively correlated with CKD progression were CCL2, CLDN1, SLC34A2, OSMR, and C1RL; however, no core genes were identified as most significantly negatively correlated with CKD development.