ECT2, TRIO, FARP1, PLEKHG2, VAV2, PREX1, and FARP2 were identified as the top-expressed Dbl-like Rac-GEFs in PCa cells, while DOCK1, DOCK5, DOCK7, and DOCK9 were the top-expressed DOCK family Rac-GEFs. This evidence concerns the gene VAV2 and posterior cortical atrophy.