RAC1 and cancer: Additionally, Rac1 regulates a diverse range of cellular functions in cancer cells, including proliferation, gene expression, metabolism, and epithelial-to-mesenchymal transition (EMT), making it an attractive target for cancer therapy (Bustelo, 2018; Kazanietz and Caloca, 2017; De et al., 2020; Casado-Medrano et al., 2019).