Interestingly, RNAi screening revealed VAV2 to be the only Rac-GEF capable of driving Rac1 activation in response to ligand-mediated stimulation of EGFR (Baker et al., 2025), an RTK with established roles in PCa progression, including metastatic dissemination (Day et al., 2017). The gene discussed is AKT1; the disease is posterior cortical atrophy.