Furthermore, it correlates strongly with bioinformatics analysis in the TCGA-PRAD human prostate carcinoma database, which reveals worse progression-free survival in PCa patients with signatures predicting “high Rac1 cell motility activity.” Rac1 deficiency also leads to significant changes in gene expression, particularly affecting transcriptional networks related to cell adhesion, ECM functions, migration, proliferation, and inflammation. The gene discussed is RAC1; the disease is prostate carcinoma.