Rac1 is often deregulated in pathological conditions, including neurological diseases and cancer (Bustelo, 2018; Kazanietz and Caloca, 2017; De et al., 2020; Casado-Medrano et al., 2019; Casado-Medrano et al., 2018; Banka et al., 2022). The gene discussed is RAC1; the disease is cancer.