Interestingly, RNAi screening revealed VAV2 to be the only Rac-GEF capable of driving Rac1 activation in response to ligand-mediated stimulation of EGFR (Baker et al., 2025), an RTK with established roles in PCa progression, including metastatic dissemination (Day et al., 2017). This evidence concerns the gene VAV2 and posterior cortical atrophy.