Obesity impairs skeletal muscle function by decreasing mobility, strength, and balance and is also linked to impaired skeletal muscle regeneration and function due to interrupted muscle metabolic processes, including insulin resistance, increased fatty acid absorption, and intramuscular fat accumulation (Tomlinson et al., 2016; Verpoorten et al., 2020). The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.