BECN1 and type 2 diabetes mellitus: One study reported that reduced the proteasomal degradation of Beclin-1 by HSPB6 exerted a cardioprotective effect,22 whereas another study found that the Beclin1 knockdown in cardiomyocytes exposed to high glucose in a model of type 2 diabetes-induced cardiomyopathy decreased apoptotic cell death.23