However, our current results showed that ketogenesis and FGF21 production—two processes under the transcriptional control of PPARα in hepatocytes45,46,47,48—were similarly induced after β3-adrenergic receptor stimulation in CD-fed and WD-fed mice, indicating that these two hepatocyte PPARα-dependent hepatic functions remained functional in WD-induced MASLD. The gene discussed is FGF21; the disease is Wilson disease.