Likewise, the levels of circulating angiotensin (1–5), angiotensin (1–7), and angiotensin (5–8) did not differ within 8 h of CFZ administration in MM patients, supporting our results of local activity of the cardiac renin-angiotensin system (RAS) after CFZ-mediated proteasome inhibition. The gene discussed is REN; the disease is Miyoshi myopathy.