Additionally, beyond the canonical kinase function in regulating Rb phosphorylation, CDK4/6 also exhibit other non-kinase functions critical to tumorigenesis, including regulation of cell motility by cytoskeletal remodeling, mitochondria activation by metabolic reprogramming, and immunomodulation by presenting tumor antigens and overexpressing PD-L1.4 The gene discussed is CDK4; the disease is neoplasm.