In this case, the possible minimum volume [dashed arrows (Fig. 6A)] is 10 to 4 times lower than the maximum tumor volume (worst case), which is achieved when CAR-T cells are injected at about the same time with anti-VEGF (first point of Fig. 6A with value of 50 cells/mm3) or after 10 days (last point of Fig. 6A with value of 50 cells/mm3). This evidence concerns the gene VEGFA and neoplasm.