Furthermore, the normalized vasculature with anti-VEGF led to about a 5-fold higher maximum number of CD8+ T cells in the tumor: the number of CD8+ T cells/mm3 is 59 and 309 for Control and anti-VEGF treated tumors, respectively, indicating that vessel normalization also increases the accumulation of CD8+ T cells in the TME. Here, CD8A is linked to neoplasm.