Given the recent research showing that lipid droplets influence disease-associated processes in AD12, 13, 15, 18, 19, 23, 26, 33, 34, we hypothesized that the molecular composition of the lipid droplets in APOE2 astrocytes and APOE4 astrocytes was different and could relate to the alleles’ divergent effects on AD risk. Here, APOE is linked to Alzheimer disease.