Recent studies identified >15 de novo mutations in the GNAI1 gene, which encodes the Gαi1 subunit of heterotrimeric G (αβγ) proteins, in individuals with a novel neurodevelopmental disorder (NDD) henceforth referred to as ‘GNAI1 disorder’ (Muir et al., 2021). Here, GNAI1 is linked to neurodevelopmental disorder.