In contrast, psoriasis exhibited a dominant IL-17 axis, with marked upregulation of CCL20, KRT6A, KRT16, and S100 family alarmins in lesional skin, some of which (e.g., SPRR2A, S100A9, IL36G) were also elevated in non-lesional samples (Fig. 1C (RNA),1D and S1C (Protein)). Here, SPRR2A is linked to psoriasis.