Most notably, CLE and DM lesions were enriched for Th1-skewed CD4+ T cells that, unlike their counterparts in vitiligo, expressed cytotoxic effector molecules including GZMB, GZMK, and PRF1, a population nearly absent in healthy and psoriasis skin (Fig. 1I, 1J, S1F, scCODA FDR < 0.1). This evidence concerns the gene PRF1 and vitiligo.