Specifically, our research reveals that ZMYND8 exhibits remarkable diagnostic performance in COAD, with an AUC value of 0.811 (95% CI: 0.913–0.961, p < 0.001), and this gene displays a notably upregulated expression trend in COAD samples, aligning with the characteristics of the ceRNA network (Figure 7). Here, ZMYND8 is linked to colon adenocarcinoma.