To further determine whether Etv1 improves cardiac function after MI, Etv1 was overexpressed in endothelium through intramyocardial injection of adeno-associated virus serotype 9 (AAV9) carrying the endothelial-specific promoter Icam2 (AAV9- Etv1) 3 days before LAD ligation. The gene discussed is ETV1; the disease is myocardial infarction.