SPP1 and acute coronary syndrome: Additionally, all three receptors have been implicated in Th17 differentiation.43,51–53 Among the CD29 subunits, α4β1, and α5β1 are the predominant integrins expressed on T lymphocytes.54,55 Furthermore, blocking CD29 or CD44 in CD4+CD45RA−CD25+ T cells stimulated with OPN, from acute coronary syndrome patients significantly decreased Th17 differentiation.43