Additionally, platelet expression of major histocompatibility complex class I (MHC-I) enables direct engagement with T-cell receptors (TCRs), promoting the expansion of effector memory CD8+ T cells (TEMRA) and driving Th1/Th17 polarization—key features of autoimmune progression in ITP [9]. The gene discussed is CD8A; the disease is autoimmune thrombocytopenic purpura.