In vivo results: KSJG granules significantly attenuated body weight, reduce liver wet weight and liver index; improve lipid accumulation and lipid metabolism disorders; increase autophagy levels in liver tissue, reduce the expression of p-Akt, p-mTOR and p-ULK1 (Ser757), and increase the expression of p-AMPK and p-ULK1 (Ser555) (P < 0.05). This evidence concerns the gene ULK1 and Disorder of lipid metabolism.