CASP3 and acute myeloid leukemia: Additionally, Western blot analysis was performed on tumor tissues derived from the xenograft model to examine the expression of PI3K/Akt/mTOR and Caspase 3/GSDME pathway proteins, aiming to determine whether FGFC1 induces pyroptosis and overcomes AML Ara-C resistance through the PI3K/Akt/mTOR signaling pathway (Jiang, 2019).