A cross-sectional study including 5634 participants with complete data on their periodontal and AF status reported that the severity of the dental plaque index was strongly associated with the prevalence of AF after adjusting for several confounders (age, sex, high-sensitivity C-reactive protein [CRP], IL-6, body mass index, diabetes, smoking, and educational level) [29]. This evidence concerns the gene CRP and atrial fibrillation.