SAMHD1 and type 1 interferonopathy: In addition, Jafarpour described a de novo mutation in RNASEH2A, which is one of the genes, along with SAMHD1 (case 12) and RNASEH2B (sibling of case 13) that can cause Aicardi-Goutières Syndrome (AGS), a type 1 interferonopathy, autoinflammatory disorder [126].