In multivariable models (Figure 3B), higher p-tau217 was associated with MCI (β=0.25, 95%CI=0.06 – 0.44, p=0.011), ADD (β=0.68, 95%CI=0.38 – 0.99, p<0.001), future progression to MCI/ADD (β=0.30, 95%CI=0.14 – 0.47, p<0.001), older age (β=0.18, 95%CI=0.11 – 0.25, p<0.001), APOE ε4 (β=0.32, 95%CI=0.18 – 0.46, p<0.001), lower eGFR (β=−0.43, 95%CI=−0.53 – −0.33, p<0.001), and histories of diabetes (β=0.21, 95%CI=0.06 – 0.37, p=0.006) and hypertension (β=−0.19, 95%CI=−0.38 – −0.00, p=0.048). This evidence concerns the gene APOE and hypertensive disorder.