APOE and diabetes mellitus: In multivariable models (Figure 3B), lower Aβ42/Aβ40 was associated with future progression to MCI/ADD (β=−0.23, 95%CI=−0.42 – −0.04, p=0.018), older age (β=−0.12, 95%CI=−0.21 – −0.03, p=0.007), APOE ε4 carriers (β=−0.23, 95%CI=−0.39 – −0.06, p=0.007), higher bilirubin (β=−0.15, 95%CI=−0.23 – −0.07, p<0.001), and a history of diabetes (β=−0.38, 95%CI=−0.55 – −0.20, p<0.001).