CXCL9-CXCR3 ligand-receptor pair exhibited the highest correlation with the macrophage-T cell colocalization scores, implicating this chemokine signaling axis as a potential critical mediator facilitating spatially organized crosstalk between these immune cells within JIA synovium (Fig. 4i-k, Supplemental Figure 4h-j). This evidence concerns the gene CXCR3 and juvenile idiopathic arthritis.