IL1RN and rheumatoid arthritis: Anti-inflammatory or tissue-repairing markers such as MRC1, CSF1R, and MERTK, which were known to be expressed on healthy synovial tissue macrophages(47) and increased in synovium of RA patients with remission states(18), showed higher expression in macrophages proximal to vasculature, whereas expression of pro-inflammatory-associated genes including IL1RN, NFKB2, and JAK2, increased with distance from the nearest endothelial cell.