The lasso model results indicated that 14 genes were linked to the occurrence of CRSwNP, including LTF, PDCD4, CDH3, CXCR4, SERPINA1, PTHLH, CPEB2, CRYAB, BCL2L15, AR, PRKCQ, TGFB1, SPIB, SEMA7A, and VTN (Figures 6A,B). This evidence concerns the gene SPIB and chronic rhinosinusitis with nasal polyps.