The lasso model results indicated that 14 genes were linked to the occurrence of CRSwNP, including LTF, PDCD4, CDH3, CXCR4, SERPINA1, PTHLH, CPEB2, CRYAB, BCL2L15, AR, PRKCQ, TGFB1, SPIB, SEMA7A, and VTN (Figures 6A,B). The gene discussed is PDCD4; the disease is chronic rhinosinusitis with nasal polyps.