AR, which is located on the X sex chromosome, encodes the androgen receptor, which is a nuclear transcription factor.In myocarditis, it was found that inhibition of androgen receptor expression reduced the production of cytokine signal inhibitors (SOCS3, SOCS1) and enhanced the activation of signal transduction and transcriptional activators (STAT3, STAT5), resulting in M2-type polarization of macrophages (Brescia et al., 2022; Ramos et al., 2022). The gene discussed is SOCS3; the disease is myocarditis.