NFKB1 and chronic rhinosinusitis with nasal polyps: Dysregulation of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs), particularly IL-17A-induced activation of the NF-κB pathway leading to MMP-9 upregulation, is a key driver of pathological tissue remodeling in chronic rhinosinusitis with nasal polyps (CRSwNP) (Watelet et al., 2004; Li et al., 2010; Kostamo et al., 2008; Chen et al., 2018).