SMAD4 and cancer: However, the expression of these miRNAs with their respective target genes on suppressing cell proliferation, migration, and invasion that directly reduced the angiogenesis of cancer cells by suppressing the expression of these three genes may provide insights on the dysregulation of these miRNAs that may influences angiogenesis impairment in HUVEC exposed to HDP through downregulation of NOTCH1, SMAD3, and SMAD4 (Wei et al., 2020; Huang et al., 2015; Li et al., 2017; Zhou et al., 2020).