Gene association tests for deletions identified NRXN1 as significantly associated with TS, with 17 cases and three controls carrying deletions that overlap coding bases (OR = 11.84 [3.20–43.83], P = 1.14E-6, adjusted P = 0.0019, consistent with Huang et al. [10] (see Fig. 4A). This evidence concerns the gene NRXN1 and Timothy syndrome.