To explore this epigenetic reprogramming, we performed immunoprecipitation following by sequencing (ChIP-seq) for the histone modifications H3K4me3 and H3K27me3 in DKO (NE-like model) and SKO (Pten KO, adenocarcinoma-like model) GEMMs. The gene discussed is PTEN; the disease is adenocarcinoma.