IL-6 plays a crucial role in both pro-inflammatory and anti-inflammatory processes.19 Its levels rise significantly during sepsis, cytokine storms, and chronic inflammation, contributing to approximately 11 million deaths globally each year.20,21 Thus, tracking IL-6 levels can serve as an early signal of severe infections and inflammatory disorders, allowing for prompt medical action.22 In healthy wound exudate, IL-6 levels are about 0.2ngml, increasing to ~3ngml in chronic wounds, whereas in sepsis, serum IL-6 levels often exceed 500pgml. This evidence concerns the gene IL6 and infection.