Lastly, in regard to malignancies, scRNAseq analyses of immune cells from the tolerized tumor microenvironment of spontaneous pancreatic tumors in the KrasLSL.G12D/+; p53R172H/+; PdxCretg/+ (KPC) mouse model for pancreatic ductal adenocarcinoma and human melanoma patients show a similar increased expression of Siglecg and Fcgr2b as well as SIGLEC10 (human homolog of Siglecg) and FCGR2B within the B cell population, respectively. The gene discussed is FCGR2B; the disease is melanoma.