Furthermore, 4 pairs were conserved in both MTG and DLPFC with AD associations (Figs. 6, a and b), including CHRNA4-choline (InN), VDR-arachidonic acid (microglia), GNAS-methylmalonic acid (InN) and TSG101-methylmalonic acid (ExN). The gene discussed is CHRNA4; the disease is Alzheimer disease.