Additionally, several GO terms related to transcriptional regulation, such as “Positive Regulation of DNA-templated Transcription” (e.g., CCNT1, ICE1) and “Positive Regulation of Nucleic Acid-Templated Transcription” (e.g., CDKN1C, TRRAP), were also enriched in CA1-Exc in AD. The gene discussed is TRRAP; the disease is Alzheimer disease.