While no CA1-specific Ast genes were linked to NFT formation in PART, several genes associated with synaptic plasticity and neuronal survival, such as HPCA and SLC44A3, were upregulated in the PART group compared to the AC and AD groups (Fig. S6C), supporting the role of Ast in counteracting neurodegeneration. The gene discussed is SLC44A3; the disease is Alzheimer disease.