The divergence of these interaction strength between AC, PART, and AD was primarily driven by changes in signaling pathways involving neurotensin (NT), pleiotrophin (PTN), macrophage migration inhibitory factor (MIF), SPP1, semaphorin 3A (SEMA3A), and prosaposin (PSAP) (Fig. 4G). Here, SPP1 is linked to Alzheimer disease.