Albeit more than 90% of GWAS signals map to non-coding regions only a few lociwere found to act on CAD through ncRNA functions, such as MIAT at the22q12.1 locus and ANRIL at the9p21 locus16, 38,which is still the strongest CAD risk locus known so far39. The gene discussed is MIAT; the disease is coronary artery disorder.