Atrial premature complexes are a type of arrythmia characterized by premature heartbeats within the atria and have been shown to be a marker of atrial cardiopathy and associated with worsened cognitive function.21 NT pro-BNP is a serum biomarker released by the myocardium and a predictor of AF, subclinical cerebrovascular disease and stroke, and has been demonstrated strongly associated with left atrial remodeling and dysfunction.24,25,26,27 Recent studies have reported a link between increased NT pro-BNP and cognitive decline and dementia.28 The gene discussed is NPPB; the disease is cerebrovascular disorder.