Strikingly, all the top proteins associated with B-cell lymphoma development (sCD23, FCMR, FCRL1, FCRL3, SELL, SEMA7A and SEMA4A) were most strongly associated with CLL development, suggesting CLL was a major driver of the top protein associations observed in the grouped analysis. The gene discussed is SEMA4A; the disease is B-cell non-Hodgkin lymphoma.