For example, research into HL has implicated an essential role for rosetting (i.e clusters of surrounding) CD4+ T-cells in Hodgkin tumor cell survival.79 These rosetting T-cells express CXCL13, CD28 and TNFRSF18, proteins that were elevated in plasma years prior to HL diagnosis in the current study.80,81 Additionally, longitudinal dynamics of early disease markers may hold potential to capture key transitions during early disease development that predict progression to overt lymphoma and aid in clinical risk stratification. Here, TNFRSF18 is linked to lymphoma.