IGSF3 and B-cell chronic lymphocytic leukemia: Trajectory analyses for the top 10 proteins associated with CLL ranked by FDR-adjusted P-value revealed increasing hazard ratios for FCMR, sCD23, SELL and IGSF3 in blood samples drawn within 5 to 10 years before diagnosis, compared to participants with blood samples drawn over 10 years before diagnosis (Fig. 2B).