MRC1 and neoplasm: Treatment with αPD1-S*significantly increased the frequency of tumor-associated macrophages(TAMs) compared to controls and within the TAM population, αPD1-S*shifted macrophage phenotypes toward M1-like, as indicated by an increasein MHCII+CD206- M1 macrophages and corresponding reduction in MHCII-CD206+M2 macrophages (Figure f).